Mortality and QTc prolongation in opioid maintenance treatment
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منابع مشابه
Dose-Dependent Effects of Methadone on QT interval in Patients under Methadone Maintenance Treatment
Background: The role of methadone in QTc prolongation, Torsades de Pointes (TdP) arrhythmia and sudden cardiac death has been debated. Because of widespread use of methadone in methadone maintenance treatment (MMT) centers, we aimed to study dose-related effects of methadone on QTc prolongation. Methods: In a comparative observational study, 90 patients who were under MMT were evaluated. Patien...
متن کاملRisk of QTc prolongation in a cohort of opioid-dependent HIV-infected patients on methadone maintenance therapy.
BACKGROUND Concern regarding the QTc interval in human immunodeficiency virus (HIV)-infected patients has been growing in recent years, and cases of prolonged QTc interval and torsades de pointes have been described in HIV-infected patients on methadone therapy. This study aimed to determine the prevalence and factors associated with long QTc interval in a cohort of opioid-dependent HIV-infecte...
متن کاملMethadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case-Control Study.
BACKGROUND Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs). A unique ME AE is its corrected QT (QTc) interval prolongation risk, but most evidence exists in methadone maintenance therapy patients. OBJECTIVE Our goal was to identify QTc interval prolongation risk factors in PPC patients receiving ME and...
متن کاملBuprenorphine as a safe alternative to methadone in a patient with acquired long QT syndrome: a case report
A 52-year-old man with a medical history of intravenous drug abuse was admitted to our hospital with syncope due to torsades de pointes (TdP). Two days earlier, he had used methadone. The electrocardiogram showed a prolonged corrected QT interval (QTc) of 600 ms. Continuous telemetry observation showed multiple episodes of TdP. The patient was diagnosed with bradyarrhythmia-induced TdP with acq...
متن کاملRetrospective analysis of low-dose methadone and QTc prolongation in chronic pain patients
BACKGROUND Methadone is a synthetic opioid that is widely used for the treatment of chronic pain. The association between methadone treatment and QT interval prolongation or which can lead to torsades de pointes has been confirmed with larger studies on high dose methadone. The aim of this study was to determine the effect of methadone on the QTc interval in patients, whether the daily dose of ...
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تاریخ انتشار 2010